Drug interactions
Eprosartan-hydrochlorothiazide + L-methylfolate
Severity: Minor
Eprosartan-hydrochlorothiazide and L-methylfolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides have been associated with modestly lower folate levels, though the clinical relevance is unclear. A meaningful loss of L-methylfolate effect is unlikely in most patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; L-methylfolate belongs to Miscellaneous.
Why it happens
Possible increased renal folate loss with thiazide diuretics; the mechanism is not firmly established.
What to do
No routine action is needed. Consider checking folate status in patients with deficiency risk or an inadequate response to supplementation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of L-methylfolate
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with L-methylfolate?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides have been associated with modestly lower folate levels, though the clinical relevance is unclear. A meaningful loss of L-methylfolate effect is unlikely in most patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and L-methylfolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Consider checking folate status in patients with deficiency risk or an inadequate response to supplementation.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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