Drug interactions
L-methylfolate + Sulphasalazine
Severity: Moderate
L-methylfolate and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine impairs folate absorption and can lead to folate deficiency, which may reduce the benefit of folate supplementation. Macrocytosis or megaloblastic anemia can result in long-term users.
What this interaction means in plain words
L-methylfolate and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
L-methylfolate belongs to Miscellaneous; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Sulfasalazine inhibits intestinal folate absorption and folate-dependent enzymes, counteracting folate repletion.
What to do
Monitor blood count and folate status in long-term therapy. Supplement folate, with the dose adjusted to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of L-methylfolate
Frequently asked questions
Can I take L-methylfolate with Sulphasalazine?
MediHelp rates the interaction as moderate. L-methylfolate and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine impairs folate absorption and can lead to folate deficiency, which may reduce the benefit of folate supplementation. Macrocytosis or megaloblastic anemia can result in long-term users.
How serious is the interaction between L-methylfolate and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood count and folate status in long-term therapy. Supplement folate, with the dose adjusted to response.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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