Drug interactions
Eprosartan-hydrochlorothiazide + Levodopa
Severity: Moderate
Eprosartan-hydrochlorothiazide and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, which adds to the blood pressure lowering of eprosartan and hydrochlorothiazide. Patients may experience dizziness or falls, particularly when starting therapy or increasing doses.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from dopaminergic vasodilation and autonomic effects with ARB and diuretic action.
What to do
Monitor blood pressure including standing readings when starting or titrating either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Levodopa?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, which adds to the blood pressure lowering of eprosartan and hydrochlorothiazide. Patients may experience dizziness or falls, particularly when starting therapy or increasing doses.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings when starting or titrating either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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