Drug interactions
Eprosartan-hydrochlorothiazide + Oliceridine
Severity: Minor
Eprosartan-hydrochlorothiazide and Oliceridine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can promote antidiuretic hormone release, which may blunt the diuretic effect of hydrochlorothiazide. Opioid-induced hypotension may also add to the effect of the antihypertensive combination, particularly in volume-depleted patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Opioid-related ADH release reduces diuresis, and additive hypotensive effects may occur.
What to do
Monitor fluid status, blood pressure and electrolytes during oliceridine therapy and adjust the diuretic dose if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Oliceridine?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can promote antidiuretic hormone release, which may blunt the diuretic effect of hydrochlorothiazide. Opioid-induced hypotension may also add to the effect of the antihypertensive combination, particularly in volume-depleted patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Oliceridine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid status, blood pressure and electrolytes during oliceridine therapy and adjust the diuretic dose if the response changes.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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