Drug interactions
Eprosartan-hydrochlorothiazide + Piperacillin
Severity: Minor
Eprosartan-hydrochlorothiazide and Piperacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may slightly reduce renal clearance of penicillins, raising piperacillin exposure. In practice the effect is small, but hypokalemia from piperacillin and hydrochlorothiazide may be additive.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Piperacillin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; both agents can lower serum potassium.
What to do
No dose change is usually needed. Monitor serum potassium and renal function during piperacillin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Piperacillin?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may slightly reduce renal clearance of penicillins, raising piperacillin exposure. In practice the effect is small, but hypokalemia from piperacillin and hydrochlorothiazide may be additive.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Piperacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor serum potassium and renal function during piperacillin therapy.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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