Drug interactions
Eprosartan-hydrochlorothiazide + Pivmecillinam
Severity: Minor
Eprosartan-hydrochlorothiazide and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecillinam and thiazides are both partly secreted by renal tubules, so reduced clearance of either is theoretically possible. Clinical consequences are not well documented and are probably minor with short courses.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; not well characterized for this pair.
What to do
No routine adjustment is required; monitor renal function and clinical response if therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Pivmecillinam?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mecillinam and thiazides are both partly secreted by renal tubules, so reduced clearance of either is theoretically possible. Clinical consequences are not well documented and are probably minor with short courses.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor renal function and clinical response if therapy is prolonged.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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