Drug interactions
Eprosartan-hydrochlorothiazide + Potassium citrate
Severity: Moderate
Eprosartan-hydrochlorothiazide and Potassium citrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan reduces aldosterone-mediated potassium excretion, so potassium supplements can cause hyperkalemia, particularly in renal impairment. The hydrochlorothiazide component promotes potassium loss and partly offsets this, but the net risk remains.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Potassium citrate belongs to Gastrointestinal Tract.
Why it happens
ARB-induced reduction in aldosterone-driven renal potassium excretion combined with added potassium load, partially opposed by thiazide kaliuresis.
What to do
Check serum potassium and renal function within the first week or two and periodically thereafter. Adjust or stop the potassium supplement if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Potassium citrate
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Potassium citrate?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eprosartan reduces aldosterone-mediated potassium excretion, so potassium supplements can cause hyperkalemia, particularly in renal impairment. The hydrochlorothiazide component promotes potassium loss and partly offsets this, but the net risk remains.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Potassium citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function within the first week or two and periodically thereafter. Adjust or stop the potassium supplement if potassium rises.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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