Drug interactions
Eprosartan-hydrochlorothiazide + Probenecid
Severity: Minor
Eprosartan-hydrochlorothiazide and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise serum uric acid and may reduce the uricosuric effect of probenecid. Thiazides also compete for renal tubular secretion, which may alter exposure to both drugs.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for organic anion secretion in the proximal tubule, together with thiazide-induced hyperuricemia that opposes uricosuric action.
What to do
Monitor serum uric acid and gout control, and adjust the probenecid dose if efficacy falls. Consider an alternative antihypertensive in patients with difficult gout.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Probenecid?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise serum uric acid and may reduce the uricosuric effect of probenecid. Thiazides also compete for renal tubular secretion, which may alter exposure to both drugs.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control, and adjust the probenecid dose if efficacy falls. Consider an alternative antihypertensive in patients with difficult gout.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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