Drug interactions
Eprosartan-hydrochlorothiazide + Quinidine
Severity: Major
Eprosartan-hydrochlorothiazide and Quinidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy description of a renal clearance interaction is poorly supported, and the clinically important concern is different. Thiazide-induced hypokalemia or hypomagnesemia can increase the risk of QT prolongation and torsades de pointes with quinidine.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Thiazide-induced hypokalemia and hypomagnesemia potentiate quinidine's QT-prolonging effect on cardiac repolarization.
What to do
Check and correct potassium and magnesium before and during quinidine therapy, and monitor the ECG for QT prolongation. Consider an alternative antihypertensive if electrolytes cannot be kept normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Quinidine?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The legacy description of a renal clearance interaction is poorly supported, and the clinically important concern is different. Thiazide-induced hypokalemia or hypomagnesemia can increase the risk of QT prolongation and torsades de pointes with quinidine.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during quinidine therapy, and monitor the ECG for QT prolongation. Consider an alternative antihypertensive if electrolytes cannot be kept normal.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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