Drug interactions
Eprosartan-hydrochlorothiazide + Sulindac
Severity: Moderate
Eprosartan-hydrochlorothiazide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac can blunt the blood pressure lowering effect of eprosartan and hydrochlorothiazide. With an ARB and a diuretic, NSAIDs increase the risk of acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium retention and reduced glomerular perfusion, counteracting the ARB and diuretic.
What to do
Monitor blood pressure, creatinine and potassium after starting sulindac, and keep the patient hydrated. Use the lowest effective dose for the shortest time or choose a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Sulindac?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac can blunt the blood pressure lowering effect of eprosartan and hydrochlorothiazide. With an ARB and a diuretic, NSAIDs increase the risk of acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting sulindac, and keep the patient hydrated. Use the lowest effective dose for the shortest time or choose a non-NSAID analgesic.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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