Drug interactions
Eprosartan-hydrochlorothiazide + Tolfenamic acid
Severity: Moderate
Eprosartan-hydrochlorothiazide and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of angiotensin receptor blockers and thiazides. In combination with a diuretic and an ARB, they raise the risk of acute kidney injury, especially with volume depletion, and may contribute to hyperkalemia.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion and impairs potassium handling, which counteracts ARB and diuretic effects.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or stopping the NSAID, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest time, or choose paracetamol where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Tolfenamic acid?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of angiotensin receptor blockers and thiazides. In combination with a diuretic and an ARB, they raise the risk of acute kidney injury, especially with volume depletion, and may contribute to hyperkalemia.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or stopping the NSAID, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest time, or choose paracetamol where appropriate.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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