Drug interactions
Eprosartan-hydrochlorothiazide + Voclosporin
Severity: Major
Eprosartan-hydrochlorothiazide and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause hyperkalemia, reduced eGFR and nephrotoxicity. Adding an ARB increases the risk of hyperkalemia and renal function decline, particularly with volume depletion from the thiazide.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive hyperkalemia and hemodynamic renal effects from calcineurin inhibition and angiotensin receptor blockade, with diuretic-related volume depletion.
What to do
Monitor serum potassium and eGFR frequently, particularly during initiation and dose changes, and reduce or stop voclosporin per label if renal function falls.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Voclosporin?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can cause hyperkalemia, reduced eGFR and nephrotoxicity. Adding an ARB increases the risk of hyperkalemia and renal function decline, particularly with volume depletion from the thiazide.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR frequently, particularly during initiation and dose changes, and reduce or stop voclosporin per label if renal function falls.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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