Drug interactions
Eptifibatide + Warfarin
Severity: Major
Eptifibatide and Warfarin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eptifibatide strongly inhibits platelet aggregation, and combined with warfarin it raises the risk of serious bleeding. Haemorrhage at access sites or internally may be significant.
What this interaction means in plain words
Eptifibatide and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eptifibatide belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of glycoprotein IIb/IIIa blockade and vitamin K antagonist anticoagulation.
What to do
Avoid unless clearly indicated and limit overlap. Monitor INR, haemoglobin and for signs of bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Eptifibatide
Frequently asked questions
Can I take Eptifibatide with Warfarin?
MediHelp rates the interaction as major. Eptifibatide and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eptifibatide strongly inhibits platelet aggregation, and combined with warfarin it raises the risk of serious bleeding. Haemorrhage at access sites or internally may be significant.
How serious is the interaction between Eptifibatide and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly indicated and limit overlap. Monitor INR, haemoglobin and for signs of bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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