Drug interactions
Erdafitinib + Hydrochlorothiazide-losartan
Severity: Minor
Erdafitinib and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is cleared mainly by CYP2C9 and CYP3A4. Losartan is a CYP2C9 substrate and not a strong inhibitor, so any effect on erdafitinib exposure is expected to be small and does not warrant the avoidance recommended for strong inhibitors.
What this interaction means in plain words
Erdafitinib and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Possible weak competition for CYP2C9 metabolism; losartan is not a clinically meaningful CYP2C9 inhibitor.
What to do
No dose change is needed; monitor for erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Erdafitinib and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is cleared mainly by CYP2C9 and CYP3A4. Losartan is a CYP2C9 substrate and not a strong inhibitor, so any effect on erdafitinib exposure is expected to be small and does not warrant the avoidance recommended for strong inhibitors.
How serious is the interaction between Erdafitinib and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity as usual.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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