Drug interactions
Erdafitinib + Imatinib
Severity: Moderate
Erdafitinib and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may raise imatinib concentrations, though imatinib is only a modest P-gp substrate. Higher imatinib exposure could increase edema, myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Erdafitinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Erdafitinib inhibits P-gp-mediated efflux of imatinib.
What to do
Separate imatinib from erdafitinib by at least 6 hours and monitor blood counts and for imatinib adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erdafitinib and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Imatinib?
MediHelp rates the interaction as moderate. Erdafitinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may raise imatinib concentrations, though imatinib is only a modest P-gp substrate. Higher imatinib exposure could increase edema, myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Erdafitinib and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate imatinib from erdafitinib by at least 6 hours and monitor blood counts and for imatinib adverse effects.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
