Drug interactions
Erdafitinib + Indomethacin
Severity: Minor
Erdafitinib and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is cleared mainly by CYP2C9 and CYP3A4. Indomethacin is a weak CYP2C9 inhibitor at most and is not a strong inhibitor, so a clinically important rise in erdafitinib exposure is unlikely.
What this interaction means in plain words
Erdafitinib and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible weak inhibition of CYP2C9-mediated erdafitinib metabolism.
What to do
No dose change is required; monitor for erdafitinib adverse effects such as hyperphosphataemia and ocular toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Indomethacin?
MediHelp rates the interaction as minor. Erdafitinib and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is cleared mainly by CYP2C9 and CYP3A4. Indomethacin is a weak CYP2C9 inhibitor at most and is not a strong inhibitor, so a clinically important rise in erdafitinib exposure is unlikely.
How serious is the interaction between Erdafitinib and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor for erdafitinib adverse effects such as hyperphosphataemia and ocular toxicity as usual.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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