Drug interactions
Erdafitinib + Irbesartan
Severity: Minor
Erdafitinib and Irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is cleared mainly by CYP2C9, and irbesartan is a CYP2C9 substrate that is not a strong inhibitor. A clinically meaningful rise in erdafitinib exposure is not expected.
What this interaction means in plain words
Erdafitinib and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Irbesartan belongs to Cardiovascular.
Why it happens
Possible weak competition at CYP2C9; irbesartan is not a strong inhibitor.
What to do
No dose change needed; monitor for erdafitinib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Irbesartan?
MediHelp rates the interaction as minor. Erdafitinib and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is cleared mainly by CYP2C9, and irbesartan is a CYP2C9 substrate that is not a strong inhibitor. A clinically meaningful rise in erdafitinib exposure is not expected.
How serious is the interaction between Erdafitinib and Irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor for erdafitinib adverse effects as usual.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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