Drug interactions
Erdafitinib + Lapatinib
Severity: Moderate
Erdafitinib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, a transporter that handles lapatinib, so lapatinib exposure may rise. Higher lapatinib levels can increase diarrhea, hepatotoxicity and QT prolongation.
What this interaction means in plain words
Erdafitinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by erdafitinib increases lapatinib absorption and reduces its efflux.
What to do
If both are needed, give lapatinib at least 6 hours before or after erdafitinib. Monitor for lapatinib adverse effects, liver tests and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Lapatinib?
MediHelp rates the interaction as moderate. Erdafitinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein, a transporter that handles lapatinib, so lapatinib exposure may rise. Higher lapatinib levels can increase diarrhea, hepatotoxicity and QT prolongation.
How serious is the interaction between Erdafitinib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, give lapatinib at least 6 hours before or after erdafitinib. Monitor for lapatinib adverse effects, liver tests and ECG.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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