Drug interactions
Erdafitinib + Memantine-donepezil
Severity: Moderate
Erdafitinib and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is an OCT2 substrate and memantine is cleared partly by renal tubular secretion involving OCT2-type transport. Competition could raise erdafitinib exposure, but the evidence is limited.
What this interaction means in plain words
Erdafitinib and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Possible competition for renal OCT2-mediated tubular secretion reduces erdafitinib clearance.
What to do
Monitor for erdafitinib adverse effects such as hyperphosphatemia, ocular and skin toxicity, and reduce the dose based on tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Memantine-donepezil?
MediHelp rates the interaction as moderate. Erdafitinib and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib is an OCT2 substrate and memantine is cleared partly by renal tubular secretion involving OCT2-type transport. Competition could raise erdafitinib exposure, but the evidence is limited.
How serious is the interaction between Erdafitinib and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib adverse effects such as hyperphosphatemia, ocular and skin toxicity, and reduce the dose based on tolerability.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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