Drug interactions
Erdafitinib + Nadolol
Severity: Moderate
Erdafitinib and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may raise exposure to P-gp substrates such as nadolol. Greater beta-blockade with bradycardia and hypotension is possible.
What this interaction means in plain words
Erdafitinib and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Nadolol belongs to Cardiovascular.
Why it happens
Erdafitinib inhibits P-glycoprotein efflux, increasing nadolol absorption and exposure.
What to do
Separate nadolol from erdafitinib by at least 6 hours as labeling advises for P-gp substrates. Monitor heart rate and blood pressure and reduce nadolol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Nadolol?
MediHelp rates the interaction as moderate. Erdafitinib and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may raise exposure to P-gp substrates such as nadolol. Greater beta-blockade with bradycardia and hypotension is possible.
How serious is the interaction between Erdafitinib and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate nadolol from erdafitinib by at least 6 hours as labeling advises for P-gp substrates. Monitor heart rate and blood pressure and reduce nadolol dose if needed.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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