Drug interactions
Erdafitinib + Nicardipine
Severity: Moderate
Erdafitinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may raise erdafitinib levels via CYP2C9 inhibition, and erdafitinib may inhibit P-gp and raise nicardipine levels. Erdafitinib toxicity includes hyperphosphatemia, ocular and nail effects, and stomatitis.
What this interaction means in plain words
Erdafitinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Possible CYP2C9 inhibition by nicardipine and P-gp inhibition by erdafitinib.
What to do
Monitor for erdafitinib adverse effects and for hypotension, and reduce the erdafitinib dose if toxicity develops. Separate erdafitinib and P-gp substrates by at least 6 hours where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Nicardipine?
MediHelp rates the interaction as moderate. Erdafitinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may raise erdafitinib levels via CYP2C9 inhibition, and erdafitinib may inhibit P-gp and raise nicardipine levels. Erdafitinib toxicity includes hyperphosphatemia, ocular and nail effects, and stomatitis.
How serious is the interaction between Erdafitinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib adverse effects and for hypotension, and reduce the erdafitinib dose if toxicity develops. Separate erdafitinib and P-gp substrates by at least 6 hours where possible.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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