Drug interactions
Erdafitinib + Paclitaxel
Severity: Moderate
Erdafitinib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, which may raise paclitaxel concentrations and increase myelosuppression and neuropathy. The clinical effect is mainly predicted from the mechanism.
What this interaction means in plain words
Erdafitinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux increases paclitaxel absorption and reduces its clearance.
What to do
If both are needed, give paclitaxel at least 6 hours before or after erdafitinib and monitor blood counts and neuropathy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Paclitaxel?
MediHelp rates the interaction as moderate. Erdafitinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein, which may raise paclitaxel concentrations and increase myelosuppression and neuropathy. The clinical effect is mainly predicted from the mechanism.
How serious is the interaction between Erdafitinib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, give paclitaxel at least 6 hours before or after erdafitinib and monitor blood counts and neuropathy.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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