Drug interactions
Erdafitinib + Quinidine
Severity: Moderate
Erdafitinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is metabolized by CYP2C9 and CYP3A4, and quinidine may modestly raise its exposure. Erdafitinib also may affect CYP3A4 substrates, so quinidine levels could change.
What this interaction means in plain words
Erdafitinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP3A4 and P-glycoprotein, and erdafitinib may alter CYP3A4 substrate exposure.
What to do
Monitor for erdafitinib toxicity, including hyperphosphatemia and ocular effects, and quinidine levels and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Quinidine?
MediHelp rates the interaction as moderate. Erdafitinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib is metabolized by CYP2C9 and CYP3A4, and quinidine may modestly raise its exposure. Erdafitinib also may affect CYP3A4 substrates, so quinidine levels could change.
How serious is the interaction between Erdafitinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib toxicity, including hyperphosphatemia and ocular effects, and quinidine levels and ECG.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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