Drug interactions
Erdafitinib + Secobarbital
Severity: Major
Erdafitinib and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce erdafitinib concentrations and decrease its efficacy in urothelial carcinoma.
What this interaction means in plain words
Erdafitinib and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erdafitinib belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP2C9 and CYP3A4 by barbiturates increases erdafitinib metabolism.
What to do
Avoid coadministration with strong inducers; select a non-inducing hypnotic. Monitor response if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Secobarbital?
MediHelp rates the interaction as major. Erdafitinib and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may reduce erdafitinib concentrations and decrease its efficacy in urothelial carcinoma.
How serious is the interaction between Erdafitinib and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration with strong inducers; select a non-inducing hypnotic. Monitor response if unavoidable.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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