Drug interactions
Erdafitinib + Varenicline
Severity: Minor
Erdafitinib and Varenicline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits OCT2, which contributes to the renal tubular secretion of varenicline. Varenicline exposure may rise, increasing nausea, sleep disturbance and other adverse effects.
What this interaction means in plain words
Erdafitinib and Varenicline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Varenicline belongs to Respiratory.
Why it happens
Erdafitinib inhibits renal OCT2-mediated tubular secretion of varenicline.
What to do
Monitor for nausea, abnormal dreams and neuropsychiatric effects. Reduce the varenicline dose if it is poorly tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erdafitinib and Varenicline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Varenicline
- Ethanol + Varenicline Moderate
- Tafenoquine + Varenicline Moderate
- Trilaciclib + Varenicline Moderate
- Cimetidine + Varenicline Minor
- Ibuprofen / famotidine + Varenicline Minor
- Nicotine inhaled + Varenicline Minor
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Varenicline?
MediHelp rates the interaction as minor. Erdafitinib and Varenicline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib inhibits OCT2, which contributes to the renal tubular secretion of varenicline. Varenicline exposure may rise, increasing nausea, sleep disturbance and other adverse effects.
How serious is the interaction between Erdafitinib and Varenicline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, abnormal dreams and neuropsychiatric effects. Reduce the varenicline dose if it is poorly tolerated.
What other medicines interact with Varenicline?
MediHelp also lists interactions of Varenicline with, for example, Ethanol, Tafenoquine, Trilaciclib. The full list is on the Varenicline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
