Drug interactions
Trilaciclib + Varenicline
Severity: Moderate
Trilaciclib and Varenicline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2 and MATE transporters involved in renal secretion of varenicline, so varenicline exposure would likely increase rather than decrease. Because trilaciclib is given only briefly around chemotherapy, the effect is likely transient.
What this interaction means in plain words
Trilaciclib and Varenicline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trilaciclib belongs to Oncology; Varenicline belongs to Respiratory.
Why it happens
Trilaciclib inhibits renal OCT2 and MATE1/MATE2-K, reducing varenicline elimination.
What to do
Monitor for varenicline adverse effects such as nausea during trilaciclib dosing, and consider pausing varenicline on chemotherapy days if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Varenicline
- Ethanol + Varenicline Moderate
- Tafenoquine + Varenicline Moderate
- Cimetidine + Varenicline Minor
- Erdafitinib + Varenicline Minor
- Ibuprofen / famotidine + Varenicline Minor
- Nicotine inhaled + Varenicline Minor
Other interactions of Trilaciclib
Frequently asked questions
Can I take Trilaciclib with Varenicline?
MediHelp rates the interaction as moderate. Trilaciclib and Varenicline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits OCT2 and MATE transporters involved in renal secretion of varenicline, so varenicline exposure would likely increase rather than decrease. Because trilaciclib is given only briefly around chemotherapy, the effect is likely transient.
How serious is the interaction between Trilaciclib and Varenicline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for varenicline adverse effects such as nausea during trilaciclib dosing, and consider pausing varenicline on chemotherapy days if symptoms occur.
What other medicines interact with Varenicline?
MediHelp also lists interactions of Varenicline with, for example, Ethanol, Tafenoquine, Cimetidine. The full list is on the Varenicline page.
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