Drug interactions
Erdafitinib + Verapamil
Severity: Moderate
Erdafitinib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as verapamil. Increased verapamil exposure could cause bradycardia, hypotension or AV block.
What this interaction means in plain words
Erdafitinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Erdafitinib inhibits intestinal and cellular P-glycoprotein efflux, reducing verapamil clearance and increasing absorption.
What to do
If coadministered, separate dosing by at least 6 hours before or after erdafitinib and monitor heart rate, blood pressure and PR interval. Reduce verapamil dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Verapamil?
MediHelp rates the interaction as moderate. Erdafitinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as verapamil. Increased verapamil exposure could cause bradycardia, hypotension or AV block.
How serious is the interaction between Erdafitinib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministered, separate dosing by at least 6 hours before or after erdafitinib and monitor heart rate, blood pressure and PR interval. Reduce verapamil dose if bradycardia or hypotension develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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