Drug interactions
Ergoloid mesylates + Itraconazole
Severity: Contraindicated
Ergoloid mesylates and Itraconazole: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise ergoloid concentrations through CYP3A4 inhibition. This could lead to ergot toxicity with vasospasm, nausea and ischemic complications.
What this interaction means in plain words
Ergoloid mesylates and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces ergoloid metabolism.
What to do
Avoid the combination and use an alternative antifungal or stop ergoloid during itraconazole therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Itraconazole?
MediHelp rates the interaction as contraindicated. Ergoloid mesylates and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole may raise ergoloid concentrations through CYP3A4 inhibition. This could lead to ergot toxicity with vasospasm, nausea and ischemic complications.
How serious is the interaction between Ergoloid mesylates and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antifungal or stop ergoloid during itraconazole therapy.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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