Drug interactions
Ergoloid mesylates + Perphenazine
Severity: Moderate
Ergoloid mesylates and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates have dopaminergic and serotonergic activity, which may oppose perphenazine's dopamine blockade. Theoretical risks include reduced antipsychotic effect or serotonergic and neuroleptic malignant syndrome features.
What this interaction means in plain words
Ergoloid mesylates and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing dopaminergic and serotonergic receptor effects; the interaction is largely theoretical.
What to do
Monitor psychiatric symptoms, temperature, rigidity and mental status. Discontinue one agent if toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Ergoloid mesylates with Perphenazine?
MediHelp rates the interaction as moderate. Ergoloid mesylates and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergoloid mesylates have dopaminergic and serotonergic activity, which may oppose perphenazine's dopamine blockade. Theoretical risks include reduced antipsychotic effect or serotonergic and neuroleptic malignant syndrome features.
How serious is the interaction between Ergoloid mesylates and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms, temperature, rigidity and mental status. Discontinue one agent if toxicity signs appear.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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