Drug interactions
Ergoloid mesylates + Ribociclib
Severity: Moderate
Ergoloid mesylates and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates are partly CYP3A4-metabolized and, like other ergot derivatives, carry a risk of vasospasm with CYP3A4 inhibition. Ribociclib may increase exposure, although the ergoloid dose is typically low.
What this interaction means in plain words
Ergoloid mesylates and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing ergoloid clearance.
What to do
Monitor for nausea, vasospastic or ischemic symptoms and hypotension. Stop ergoloid if such symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Ribociclib?
MediHelp rates the interaction as moderate. Ergoloid mesylates and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergoloid mesylates are partly CYP3A4-metabolized and, like other ergot derivatives, carry a risk of vasospasm with CYP3A4 inhibition. Ribociclib may increase exposure, although the ergoloid dose is typically low.
How serious is the interaction between Ergoloid mesylates and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, vasospastic or ischemic symptoms and hypotension. Stop ergoloid if such symptoms develop.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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