Drug interactions
Ergoloid mesylates + Voriconazole
Severity: Contraindicated
Ergoloid mesylates and Voriconazole: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase ergoloid exposure, with a risk of ergot toxicity including vasospasm and ischemia.
What this interaction means in plain words
Ergoloid mesylates and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Strong CYP3A4 inhibition by voriconazole reduces ergoloid metabolism.
What to do
Avoid the combination; stop ergoloid or select a non-azole antifungal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Voriconazole?
MediHelp rates the interaction as contraindicated. Ergoloid mesylates and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole may increase ergoloid exposure, with a risk of ergot toxicity including vasospasm and ischemia.
How serious is the interaction between Ergoloid mesylates and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; stop ergoloid or select a non-azole antifungal.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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