Drug interactions
Ergonovine + Ribociclib
Severity: Major
Ergonovine and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergonovine is metabolized by CYP3A4, and elevated levels of ergot alkaloids can cause severe vasospasm and ischemia. Ribociclib may increase ergonovine exposure.
What this interaction means in plain words
Ergonovine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by ribociclib decreases ergonovine metabolism.
What to do
Avoid the combination where possible, or use the lowest effective ergonovine dose for the shortest time. Monitor for peripheral ischemia and hypertension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ergonovine with Ribociclib?
MediHelp rates the interaction as major. Ergonovine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergonovine is metabolized by CYP3A4, and elevated levels of ergot alkaloids can cause severe vasospasm and ischemia. Ribociclib may increase ergonovine exposure.
How serious is the interaction between Ergonovine and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective ergonovine dose for the shortest time. Monitor for peripheral ischemia and hypertension.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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