Drug interactions
Eribulin + Flecainide
Severity: Major
Eribulin and Flecainide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and flecainide has proarrhythmic effects on conduction and repolarization. Together they may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Eribulin and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Flecainide belongs to Cardiovascular.
Why it happens
Additive effects on cardiac repolarization.
What to do
If coadministration is necessary, perform ECG monitoring at baseline and during treatment, and correct potassium and magnesium. Consider an alternative antiarrhythmic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eribulin and Flecainide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Flecainide?
MediHelp rates the interaction as major. Eribulin and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval, and flecainide has proarrhythmic effects on conduction and repolarization. Together they may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Eribulin and Flecainide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is necessary, perform ECG monitoring at baseline and during treatment, and correct potassium and magnesium. Consider an alternative antiarrhythmic.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
