Drug interactions
Eribulin + Fluoxetine
Severity: Moderate
Eribulin and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and fluoxetine may add to this effect. The combination may increase the risk of ventricular arrhythmias, particularly with electrolyte disturbances.
What this interaction means in plain words
Eribulin and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform ECG monitoring and correct hypokalemia and hypomagnesemia before and during eribulin therapy. Consider an alternative antidepressant if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Fluoxetine?
MediHelp rates the interaction as moderate. Eribulin and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and fluoxetine may add to this effect. The combination may increase the risk of ventricular arrhythmias, particularly with electrolyte disturbances.
How serious is the interaction between Eribulin and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring and correct hypokalemia and hypomagnesemia before and during eribulin therapy. Consider an alternative antidepressant if QTc becomes significantly prolonged.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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