Drug interactions
Eribulin + Histrelin
Severity: Moderate
Eribulin and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with histrelin can prolong the QT interval, and eribulin has the same effect. Together they may increase torsades de pointes risk.
What this interaction means in plain words
Eribulin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; GnRH agonist-induced androgen suppression affects cardiac repolarization.
What to do
Obtain baseline and periodic ECGs and correct electrolyte abnormalities. Reassess the need for both agents in patients with prior QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Eribulin with Histrelin?
MediHelp rates the interaction as moderate. Eribulin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with histrelin can prolong the QT interval, and eribulin has the same effect. Together they may increase torsades de pointes risk.
How serious is the interaction between Eribulin and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct electrolyte abnormalities. Reassess the need for both agents in patients with prior QT prolongation.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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