Drug interactions
Eribulin + Maprotiline
Severity: Major
Eribulin and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and maprotiline may add to this effect, raising the risk of ventricular arrhythmias. The risk is higher with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Eribulin and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Consider an alternative antidepressant during eribulin therapy. If combined, check ECG and correct potassium and magnesium before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Maprotiline?
MediHelp rates the interaction as major. Eribulin and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval and maprotiline may add to this effect, raising the risk of ventricular arrhythmias. The risk is higher with electrolyte abnormalities or heart disease.
How serious is the interaction between Eribulin and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antidepressant during eribulin therapy. If combined, check ECG and correct potassium and magnesium before and during treatment.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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