Drug interactions
Eribulin + Sertraline
Severity: Moderate
Eribulin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, particularly early in treatment. Sertraline may add a small effect, so arrhythmia risk is higher in patients with electrolyte disturbance or heart disease.
What this interaction means in plain words
Eribulin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG and correct hypokalemia and hypomagnesemia before and during eribulin. Avoid eribulin in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Sertraline?
MediHelp rates the interaction as moderate. Eribulin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, particularly early in treatment. Sertraline may add a small effect, so arrhythmia risk is higher in patients with electrolyte disturbance or heart disease.
How serious is the interaction between Eribulin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct hypokalemia and hypomagnesemia before and during eribulin. Avoid eribulin in congenital long QT syndrome.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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