Drug interactions
Eribulin + Voclosporin
Severity: Moderate
Eribulin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin prolongs the QT interval, and voclosporin has also shown QT prolongation at supratherapeutic exposures. Combined use could increase arrhythmia risk, mainly in patients with predisposing cardiac or electrolyte problems.
What this interaction means in plain words
Eribulin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Monitor the ECG and serum electrolytes, correcting potassium and magnesium deficits. Reassess the combination if the QTc rises significantly or symptoms such as syncope or palpitations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Eribulin with Voclosporin?
MediHelp rates the interaction as moderate. Eribulin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin prolongs the QT interval, and voclosporin has also shown QT prolongation at supratherapeutic exposures. Combined use could increase arrhythmia risk, mainly in patients with predisposing cardiac or electrolyte problems.
How serious is the interaction between Eribulin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and serum electrolytes, correcting potassium and magnesium deficits. Reassess the combination if the QTc rises significantly or symptoms such as syncope or palpitations occur.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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