Drug interactions
Erlotinib + Mifepristone
Severity: Moderate
Erlotinib and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise erlotinib concentrations through CYP3A4 inhibition, increasing the risk of rash, diarrhea and other adverse effects. The effect is of most concern during chronic mifepristone use.
What this interaction means in plain words
Erlotinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone reduces the metabolism of erlotinib.
What to do
Monitor for erlotinib toxicity and reduce the erlotinib dose in stepwise decrements if severe reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Mifepristone?
MediHelp rates the interaction as moderate. Erlotinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may raise erlotinib concentrations through CYP3A4 inhibition, increasing the risk of rash, diarrhea and other adverse effects. The effect is of most concern during chronic mifepristone use.
How serious is the interaction between Erlotinib and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity and reduce the erlotinib dose in stepwise decrements if severe reactions occur.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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