Drug interactions
Erlotinib + Nicardipine
Severity: Minor
Erlotinib and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit P-glycoprotein and could slightly raise erlotinib exposure. Clinical relevance is uncertain and increased rash or diarrhea would be the expected signs.
What this interaction means in plain words
Erlotinib and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erlotinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Possible inhibition of P-glycoprotein efflux of erlotinib by nicardipine.
What to do
No routine change needed. Monitor for erlotinib adverse effects such as diarrhea and rash.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Nicardipine?
MediHelp rates the interaction as minor. Erlotinib and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may inhibit P-glycoprotein and could slightly raise erlotinib exposure. Clinical relevance is uncertain and increased rash or diarrhea would be the expected signs.
How serious is the interaction between Erlotinib and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Monitor for erlotinib adverse effects such as diarrhea and rash.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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