Drug interactions
Erlotinib + Quinidine
Severity: Minor
Erlotinib and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and might slightly increase erlotinib exposure. The effect is likely small and based on theory.
What this interaction means in plain words
Erlotinib and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erlotinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits P-glycoprotein efflux of erlotinib.
What to do
No routine adjustment is needed. Monitor for rash, diarrhea and other erlotinib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Quinidine?
MediHelp rates the interaction as minor. Erlotinib and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine inhibits P-glycoprotein and might slightly increase erlotinib exposure. The effect is likely small and based on theory.
How serious is the interaction between Erlotinib and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for rash, diarrhea and other erlotinib adverse effects.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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