Drug interactions
Erlotinib + Secobarbital
Severity: Moderate
Erlotinib and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce CYP3A4 and lower erlotinib exposure, which could reduce antitumour efficacy. Strong inducers are known to lower erlotinib levels substantially.
What this interaction means in plain words
Erlotinib and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
CYP3A4 induction by secobarbital increases the hepatic metabolism of erlotinib.
What to do
Prefer a non-inducing alternative to secobarbital. If it is unavoidable, consider increasing the erlotinib dose cautiously while monitoring tolerability, and reduce it again after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Secobarbital?
MediHelp rates the interaction as moderate. Erlotinib and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may induce CYP3A4 and lower erlotinib exposure, which could reduce antitumour efficacy. Strong inducers are known to lower erlotinib levels substantially.
How serious is the interaction between Erlotinib and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing alternative to secobarbital. If it is unavoidable, consider increasing the erlotinib dose cautiously while monitoring tolerability, and reduce it again after the inducer is stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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