Drug interactions
Erythromycin + Histrelin
Severity: Moderate
Erythromycin and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as histrelin can prolong the QT interval, and erythromycin also prolongs QT. Combined use may increase the risk of torsade de pointes.
What this interaction means in plain words
Erythromycin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation from erythromycin ion-channel blockade and GnRH agonist-induced androgen suppression.
What to do
Check baseline ECG and electrolytes, and correct hypokalemia or hypomagnesemia. Choose a non-QT-prolonging antibiotic if the patient has other cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Erythromycin with Histrelin?
MediHelp rates the interaction as moderate. Erythromycin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as histrelin can prolong the QT interval, and erythromycin also prolongs QT. Combined use may increase the risk of torsade de pointes.
How serious is the interaction between Erythromycin and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and correct hypokalemia or hypomagnesemia. Choose a non-QT-prolonging antibiotic if the patient has other cardiac risk factors.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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