Drug interactions
Erythromycin + Isavuconazonium
Severity: Minor
Erythromycin and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and erythromycin is a moderate CYP3A4 inhibitor that may modestly raise its levels. Labeling restricts only strong CYP3A4 inhibitors, and moderate inhibitors are not expected to require adjustment. The clinical effect is likely small.
What this interaction means in plain words
Erythromycin and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Isavuconazonium belongs to Anti Fungals.
Why it happens
Erythromycin may modestly inhibit CYP3A4-mediated metabolism of isavuconazole.
What to do
No dose change is generally needed. Monitor for isavuconazole adverse effects such as hepatic enzyme elevation and QT shortening.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erythromycin and Isavuconazonium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Erythromycin with Isavuconazonium?
MediHelp rates the interaction as minor. Erythromycin and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate, and erythromycin is a moderate CYP3A4 inhibitor that may modestly raise its levels. Labeling restricts only strong CYP3A4 inhibitors, and moderate inhibitors are not expected to require adjustment. The clinical effect is likely small.
How serious is the interaction between Erythromycin and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for isavuconazole adverse effects such as hepatic enzyme elevation and QT shortening.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
