Drug interactions
Erythromycin + Lemborexant
Severity: Major
Erythromycin and Lemborexant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin increases lemborexant exposure, which may cause excessive somnolence and next-day impairment.
What this interaction means in plain words
Erythromycin and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Lemborexant belongs to Central Nervous System.
Why it happens
Erythromycin inhibits CYP3A4, reducing lemborexant clearance.
What to do
Limit lemborexant to the reduced maximum dose recommended with moderate CYP3A inhibitors, or choose another antibiotic. Counsel on next-day drowsiness.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Erythromycin with Lemborexant?
MediHelp rates the interaction as major. Erythromycin and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin increases lemborexant exposure, which may cause excessive somnolence and next-day impairment.
How serious is the interaction between Erythromycin and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the reduced maximum dose recommended with moderate CYP3A inhibitors, or choose another antibiotic. Counsel on next-day drowsiness.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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