Drug interactions
Erythromycin + Lenacapavir
Severity: Moderate
Erythromycin and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may increase erythromycin exposure, including its gastrointestinal effects and QT prolongation risk. The inhibition may persist for months after the last subcutaneous dose.
What this interaction means in plain words
Erythromycin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing erythromycin metabolism.
What to do
Monitor for erythromycin adverse effects, and consider an ECG in patients with QT risk factors. Consider an alternative antibiotic such as azithromycin if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Erythromycin with Lenacapavir?
MediHelp rates the interaction as moderate. Erythromycin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor and may increase erythromycin exposure, including its gastrointestinal effects and QT prolongation risk. The inhibition may persist for months after the last subcutaneous dose.
How serious is the interaction between Erythromycin and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erythromycin adverse effects, and consider an ECG in patients with QT risk factors. Consider an alternative antibiotic such as azithromycin if appropriate.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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