Drug interactions
Erythromycin + Leniolisib
Severity: Minor
Erythromycin and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3, which could modestly raise exposure to erythromycin. The clinical consequence is uncertain and likely small.
What this interaction means in plain words
Erythromycin and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib inhibits hepatic OATP uptake transporters, possibly reducing erythromycin hepatic uptake.
What to do
No dose change is usually required; monitor for erythromycin adverse effects such as gastrointestinal intolerance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Erythromycin with Leniolisib?
MediHelp rates the interaction as minor. Erythromycin and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits OATP1B1 and OATP1B3, which could modestly raise exposure to erythromycin. The clinical consequence is uncertain and likely small.
How serious is the interaction between Erythromycin and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for erythromycin adverse effects such as gastrointestinal intolerance.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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