Drug interactions
Erythromycin + Lurbinectedin
Severity: Major
Erythromycin and Lurbinectedin: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase lurbinectedin exposure, raising the risk of myelosuppression and hepatotoxicity.
What this interaction means in plain words
Erythromycin and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Lurbinectedin belongs to Oncology.
Why it happens
Erythromycin inhibits CYP3A4, which is the main route of lurbinectedin metabolism.
What to do
Avoid the combination and choose a non-inhibiting antibiotic. If unavoidable, consider reducing the lurbinectedin dose per labeling and monitor blood counts and liver tests.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Erythromycin with Lurbinectedin?
MediHelp rates the interaction as major. Erythromycin and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may increase lurbinectedin exposure, raising the risk of myelosuppression and hepatotoxicity.
How serious is the interaction between Erythromycin and Lurbinectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inhibiting antibiotic. If unavoidable, consider reducing the lurbinectedin dose per labeling and monitor blood counts and liver tests.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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