Drug interactions
Erythromycin + Naldemedine
Severity: Moderate
Erythromycin and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may raise naldemedine concentrations since naldemedine is a CYP3A4 and P-glycoprotein substrate. Higher exposure may cause more abdominal pain, diarrhea and, in some patients, opioid withdrawal-like symptoms.
What this interaction means in plain words
Erythromycin and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Erythromycin inhibits CYP3A4 and P-glycoprotein, reducing naldemedine metabolism and efflux.
What to do
Monitor for gastrointestinal adverse effects and opioid withdrawal symptoms. Stop naldemedine if severe or persistent diarrhea develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Erythromycin with Naldemedine?
MediHelp rates the interaction as moderate. Erythromycin and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may raise naldemedine concentrations since naldemedine is a CYP3A4 and P-glycoprotein substrate. Higher exposure may cause more abdominal pain, diarrhea and, in some patients, opioid withdrawal-like symptoms.
How serious is the interaction between Erythromycin and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and opioid withdrawal symptoms. Stop naldemedine if severe or persistent diarrhea develops.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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