Drug interactions
Erythromycin + Naloxegol
Severity: Moderate
Erythromycin and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin increases naloxegol concentrations, which may precipitate opioid withdrawal symptoms and gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Erythromycin and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Erythromycin inhibits CYP3A4 and P-glycoprotein, reducing naloxegol clearance.
What to do
Reduce naloxegol to 12.5 mg daily if combined, and monitor for withdrawal symptoms or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Erythromycin with Naloxegol?
MediHelp rates the interaction as moderate. Erythromycin and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin increases naloxegol concentrations, which may precipitate opioid withdrawal symptoms and gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Erythromycin and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce naloxegol to 12.5 mg daily if combined, and monitor for withdrawal symptoms or abdominal pain.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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